Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
Summary: Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic lateral sclerosis and frontotemporal degeneration. The molecular changes associated with the loss of nuclear TDP-43 in human...
Main Authors: | Elaine Y. Liu, Jenny Russ, Christopher P. Cali, Jessica M. Phan, Alexandre Amlie-Wolf, Edward B. Lee |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-04-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719304589 |
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