PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway

PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway

Abstract Background Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air pollution that damages lung cells. However, the mechanisms remain to be e...

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Main Authors: Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang, Yuh-Lien Chen
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Particle and Fibre Toxicology
Subjects:
Particulate matters (PMs)
Intercellular adhesion molecule-1 (ICAM-1)
Reactive oxygen species (ROS)
Interleukin-6 (IL-6)
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12989-018-0240-x

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http://link.springer.com/article/10.1186/s12989-018-0240-x

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