A balanced IL-1β activity is required for host response to Citrobacter rodentium infection.

A balanced IL-1β activity is required for host response to Citrobacter rodentium infection.

Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for the maturation of interleukin (IL)-1β. Our aim was to delineate the role of the NLRP3 inflammasome in macrophages, and the contribution o...

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Bibliographic Details
Main Authors: Misagh Alipour, Yuefei Lou, Daniel Zimmerman, Michael W Bording-Jorgensen, Consolato Sergi, Julia J Liu, Eytan Wine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3846666?pdf=render

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http://europepmc.org/articles/PMC3846666?pdf=render

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