MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling

MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling

MicroRNA-21 (miR-21) is one of the most frequently upregulated miRNAs in liver diseases such as nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). However, mechanistic pathways that connect NAFLD and HCC remain elusive. We developed a doxycycline (Dox)-inducible transgenic...

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Bibliographic Details
Main Authors: Chi-Yu Lai, Kun-Yun Yeh, Chiu-Ya Lin, Yang-Wen Hsieh, Hsin-Hung Lai, Jim-Ray Chen, Chia-Chun Hsu, Guor Mour Her
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
microRNAs
hepatic steatosis
steatohepatitis
fibrogenesis
liver cancer
Online Access:https://www.mdpi.com/2072-6694/13/5/940

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https://www.mdpi.com/2072-6694/13/5/940

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