Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals

Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals

Age is a major risk factor for COVID-19 severity, and T cells play a central role in anti-SARS-CoV-2 immunity. Because SARS-CoV-2-cross-reactive T cells have been detected in unexposed individuals, we investigated the age-related differences in pre-existing SARS-CoV-2-reactive T cells. SARS-CoV-2-re...

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Bibliographic Details
Main Authors: Norihide Jo, Rui Zhang, Hideki Ueno, Takuya Yamamoto, Daniela Weiskopf, Miki Nagao, Shinya Yamanaka, Yoko Hamazaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging
Subjects:
SARS-CoV-2
COVID-19
T-cell immunity
cross-reactive T cells
senescent T cells
cytomegalovirus
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2021.719342/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2021.719342/full

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