Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals
Age is a major risk factor for COVID-19 severity, and T cells play a central role in anti-SARS-CoV-2 immunity. Because SARS-CoV-2-cross-reactive T cells have been detected in unexposed individuals, we investigated the age-related differences in pre-existing SARS-CoV-2-reactive T cells. SARS-CoV-2-re...
Main Authors: | Norihide Jo, Rui Zhang, Hideki Ueno, Takuya Yamamoto, Daniela Weiskopf, Miki Nagao, Shinya Yamanaka, Yoko Hamazaki |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
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Series: | Frontiers in Aging |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2021.719342/full |
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