Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis

Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis

Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis characterized by progressive joint destruction. IL-17-producing CD4+ T (Th17) cells play pivotal roles in RA development and progression. Retinoic acid receptor-related orphan receptor alpha (RORα) is a negative regulator of inflammat...

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Bibliographic Details
Main Authors: Jin-Sil Park, Su-Jin Moon, Mi-Ae Lim, Jae-Kyeong Byun, Sun-Hee Hwang, SeungCheon Yang, Eun-Kyung Kim, Hohyun Lee, Sung-Min Kim, Jennifer Lee, Seung-Ki Kwok, Jun-Ki Min, Mi-Ock Lee, Dong-Yun Shin, Sung-Hwan Park, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
RORα
IL-17-producing T cells
regulatory T cells
osteoclastogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02270/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02270/full

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