Lamin A/C Assembly Defects in <i>LMNA</i>-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

Lamin A/C Assembly Defects in <i>LMNA</i>-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

<i>LMNA</i> encodes for Lamin A/C, type V intermediate filaments that polymerize under the inner nuclear membrane to form the nuclear lamina. A small fraction of Lamin A/C, less polymerized, is also found in the nucleoplasm. Lamin A/C functions include roles in nuclear resistance to mech...

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Bibliographic Details
Main Authors: Anne T. Bertrand, Astrid Brull, Feriel Azibani, Louise Benarroch, Khadija Chikhaoui, Colin L. Stewart, Ohad Medalia, Rabah Ben Yaou, Gisèle Bonne
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
Emery–Dreifuss muscular dystrophy
<i>LMNA</i>-related congenital muscular dystrophy
Lamin A/C
<i>LMNA</i>
Online Access:https://www.mdpi.com/2073-4409/9/4/844

Internet

https://www.mdpi.com/2073-4409/9/4/844

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