TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

The abnormal mislocalisation and ubiquitinated protein aggregation of the TAR DNA binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous system (CNS) is a pathological hallmark of early-onset neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and fro...

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Bibliographic Details
Main Authors: Fiona Bright, Gabriella Chan, Annika van Hummel, Lars M. Ittner, Yazi D. Ke
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
TDP-43
neuroinflammation
neurodegeneration
immunity
ALS
FTD
Online Access:https://www.mdpi.com/1422-0067/22/15/7781

Internet

https://www.mdpi.com/1422-0067/22/15/7781

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