Development of gel-filter method for high enrichment of low-molecular weight proteins from serum.

The human serum proteome has been extensively screened for biomarkers. However, the large dynamic range of protein concentrations in serum and the presence of highly abundant and large molecular weight proteins, make identification and detection changes in the amount of low-molecular weight proteins...

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Bibliographic Details
Main Authors: Lingsheng Chen, Linhui Zhai, Yanchang Li, Ning Li, Chengpu Zhang, Lingyan Ping, Lei Chang, Junzhu Wu, Xiangping Li, Deshun Shi, Ping Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115862