Loss of Long-Term Potentiation at Hippocampal Output Synapses in Experimental Temporal Lobe Epilepsy

Loss of Long-Term Potentiation at Hippocampal Output Synapses in Experimental Temporal Lobe Epilepsy

Patients suffering from temporal lobe epilepsy (TLE) show severe problems in hippocampus dependent memory consolidation. Memory consolidation strongly depends on an intact dialog between the hippocampus and neocortical structures. Deficits in hippocampal signal transmission are known to provoke dist...

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Bibliographic Details
Main Authors: Sabine Grosser, Nadine Buck, Karl-Heinz Braunewell, Kate E. Gilling, Christian Wozny, Pawel Fidzinski, Joachim Behr
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hippocampus
subiculum
temporal lobe epilepsy (TLE)
long-term potentiation
synaptic plasticitiy
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00143/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00143/full

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