Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA

Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA

Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain. The structure of TLR9 and its biochemical analyse...

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Bibliographic Details
Main Authors: Ryutaro Fukui, Chikako Yamamoto, Fumi Matsumoto, Masahiro Onji, Takuma Shibata, Yusuke Murakami, Atsuo Kanno, Takuto Hayashi, Natsuko Tanimura, Nobuaki Yoshida, Kensuke Miyake
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor 9
proteolytic cleavage
Unc93 homolog B1
CpG-ODN
primary immune cells
in vivo response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01491/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01491/full

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