The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegan...

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Bibliographic Details
Main Authors: Gunther Hollopeter, Jeffrey J Lange, Ying Zhang, Thien N Vu, Mingyu Gu, Michael Ailion, Eric J Lambie, Brian D Slaughter, Jay R Unruh, Laurence Florens, Erik M Jorgensen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
endocytosis
clathrin adaptor complex
AP2
protein conformation
FCHo protein
SGIP1
Online Access:https://elifesciences.org/articles/03648

Internet

https://elifesciences.org/articles/03648

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