Identification of a fatty acid Δ6-desaturase deficiency in human skin fibroblasts

Identification of a fatty acid Δ6-desaturase deficiency in human skin fibroblasts

Polyunsaturated fatty acid (PUFA) utilization was investigated in skin fibroblasts cultured from a female patient with an inherited abnormality in lipid metabolism. These deficient human skin fibroblasts (DF) converted 85–95% less [1-14C]linoleic acid (18:2n-6) to arachidonic acid (20:4n-6), 95% les...

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Bibliographic Details
Main Authors: Deborah E. Williard, Joseph O. Nwankwo, Terry L. Kaduce, Shawn D. Harmon, Mira Irons, Hugo W. Moser, Gerald V. Raymond, Arthur A. Spector
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Journal of Lipid Research
Subjects:
polyunsaturated fatty acids
fatty acid desaturation
Δ5-desaturase
linoleic acid
α-linolenic acid
arachidonic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520303680

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http://www.sciencedirect.com/science/article/pii/S0022227520303680

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