PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis

PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis

Abstract Background Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexp...

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Bibliographic Details
Main Authors: Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang, Ni Tang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Phosphoenolpyruvate carboxykinase 1
Hepatocellular carcinoma
Cell cycle arrest
CDK/Rb/E2F pathway
AMP-activated protein kinase
Online Access:http://link.springer.com/article/10.1186/s13046-019-1029-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1029-y

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