A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress

A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress

Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively. While protective EETs are degraded by soluble epoxide hydrolase (sEH) very fast. We have reported that dual inhibition of COX-2 and sEH with...

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Bibliographic Details
Main Authors: Yan-Feng Zhang, Chen-Chen Sun, Jia-Xi Duan, Hui-Hui Yang, Chen-Yu Zhang, Jian-Bing Xiong, Wen-Jing Zhong, Cheng Zu, Xin-Xin Guan, Hui-Ling Jiang, Bruce D. Hammock, Sung Hee Hwang, Yong Zhou, Cha-Xiang Guan
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sepsis
Dual COX-2 and sEH inhibitor
NLRP3 inflamma some
Oxidative stress
Multiple organ dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220300974

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http://www.sciencedirect.com/science/article/pii/S0753332220300974

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