Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesis

Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesis

Abstract Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) are symptomatically characterized by parkinsonism, with the latter presenting additionally a distinctive range of atypical features. Although the majority of patients with PD and APS appear to be sporadic, genetic causes of...

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Bibliographic Details
Main Authors: Stefanie Smolders, Christine Van Broeckhoven
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
Vesicular trafficking defects
Lysosomal dysfunction
Mitochondrial dysfunction
Lysosomal storage disorder genes
Oligogenic and polygenic inheritance
Online Access:http://link.springer.com/article/10.1186/s40478-020-00935-4

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http://link.springer.com/article/10.1186/s40478-020-00935-4

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