Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

Summary: The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin alters mesothelial cells in the omental microenvironment. Metformin interrupts bidirectional signaling b...

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Bibliographic Details
Main Authors: Peter C. Hart, Hilary A. Kenny, Niklas Grassl, Karen M. Watters, Lacey M. Litchfield, Fabian Coscia, Ivana Blaženović, Lisa Ploetzky, Oliver Fiehn, Matthias Mann, Ernst Lengyel, Iris L. Romero
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315700

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http://www.sciencedirect.com/science/article/pii/S2211124719315700

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