Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
Summary: The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin alters mesothelial cells in the omental microenvironment. Metformin interrupts bidirectional signaling b...
Main Authors: | Peter C. Hart, Hilary A. Kenny, Niklas Grassl, Karen M. Watters, Lacey M. Litchfield, Fabian Coscia, Ivana Blaženović, Lisa Ploetzky, Oliver Fiehn, Matthias Mann, Ernst Lengyel, Iris L. Romero |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719315700 |
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