The adverse effect of selective cyclooxygenase-2 inhibitor on random skin flap survival in rats.

BACKGROUND: Cyclooxygenase-2(COX-2) inhibitors provide desired analgesic effects after injury or surgery, but evidences suggested they also attenuate wound healing. The study is to investigate the effect of COX-2 inhibitor on random skin flap survival. METHODS: The McFarlane flap model was establish...

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Bibliographic Details
Main Authors: Haiyong Ren, Dingsheng Lin, Zhenyu Mou, Pu Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855778?pdf=render