Activation of the IGF Axis in Thyroid Cancer: Implications for Tumorigenesis and Treatment

Activation of the IGF Axis in Thyroid Cancer: Implications for Tumorigenesis and Treatment

The Insulin-like growth factor (IGF) axis is one of the best-established drivers of thyroid transformation, as thyroid cancer cells overexpress both IGF ligands and their receptors. Thyroid neoplasms encompass distinct clinical and biological entities as differentiated thyroid carcinomas (DTC)&#...

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Bibliographic Details
Main Authors: Livia Manzella, Michele Massimino, Stefania Stella, Elena Tirrò, Maria Stella Pennisi, Federica Martorana, Gianmarco Motta, Silvia Rita Vitale, Adriana Puma, Chiara Romano, Sandra Di Gregorio, Marco Russo, Pasqualino Malandrino, Paolo Vigneri
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
IGF axis
thyroid cancer
therapeutic approach
Online Access:https://www.mdpi.com/1422-0067/20/13/3258

Internet

https://www.mdpi.com/1422-0067/20/13/3258

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