Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic targets remain largely uncharacteriz...

Full description

Bibliographic Details
Main Authors: Shreyasi Mukherjee, Praneet Chaturvedi, Scott A Rankin, Margaret B Fish, Marcin Wlizla, Kitt D Paraiso, Melissa MacDonald, Xiaoting Chen, Matthew T Weirauch, Ira L Blitz, Ken WY Cho, Aaron M Zorn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
Wnt
sox17
beta-catenin
transcription
endoderm
enhancers
Online Access:https://elifesciences.org/articles/58029

Internet

https://elifesciences.org/articles/58029

Similar Items