A novel approach to pharmacodynamic assessment of antimicrobial agents: new insights to dosing regimen design.

Pharmacodynamic modeling has been increasingly used as a decision support tool to guide dosing regimen selection, both in the drug development and clinical settings. Killing by antimicrobial agents has been traditionally classified categorically as concentration-dependent (which would favor less fra...

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Bibliographic Details
Main Authors: Vincent H Tam, Michael Nikolaou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3017105?pdf=render