Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.

Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.

Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Interleukin-6 (IL-6) is a major mediator of inflammation and contributor to carcinogenesis within the biliary tree. Previous studies suggested that enforced IL-6 contributes to cholangiocarcinogene...

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Bibliographic Details
Main Authors: Fangmei An, Sumitaka Yamanaka, Sarah Allen, Lewis R Roberts, Gregory J Gores, Timothy M Pawlik, Qing Xie, Masaharu Ishida, Esteban Mezey, Anne C Ferguson-Smith, Yuriko Mori, Florin M Selaru
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3478287?pdf=render

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http://europepmc.org/articles/PMC3478287?pdf=render

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