Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II

Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II

Lung-specific overexpression of prostacyclin synthase (PGIS) decreases tumor initiation in murine lung cancer models. Prostacyclin analogs prevent lung tumor formation in mice and reverse bronchial dysplasia in former smokers. However, the effect of prostacyclin on lung cancer progression has not be...

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Bibliographic Details
Main Authors: Howard Y. Li, Maria McSharry, Deandra Walker, Amber Johnson, Jeff Kwak, Bonnie Bullock, Alexander Neuwelt, Joanna M. Poczobutt, Trisha R. Sippel, Robert L. Keith, Mary C. M. Weiser-Evans, Eric Clambey, Raphael A. Nemenoff
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
lung cancer
lymphocytes
prostacyclin
prostaglandins
tumor immunology
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1423182

Internet

http://dx.doi.org/10.1080/2162402X.2017.1423182

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