Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Strategies to prevent diabetic microvascular angiopathy focus on the vascular endothelium. Because red blood cells (RBCs) are less deformable in diabetes, we explored an original concept linking decreased RBC deformability to RBC ascorbate and hyperglycemia. We characterized ascorbate concentrations...

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Bibliographic Details
Main Authors: Hongbin Tu, Hongyan Li, Yu Wang, Mahtab Niyyati, Yaohui Wang, Jonathan Leshin, Mark Levine
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
Ascorbic Acid
Dehydroascorbic Acid
Red Blood Cells
Diabetes
Glucose Transport
β-Spectrin***
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641530164X

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http://www.sciencedirect.com/science/article/pii/S235239641530164X

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