An Improved Synthesis of Key Intermediate to the Formation of Selected Indolin-2-Ones Derivatives Incorporating Ultrasound and Deep Eutectic Solvent (DES) Blend of Techniques, for Some Biological Activities and Molecular Docking Studies

An Improved Synthesis of Key Intermediate to the Formation of Selected Indolin-2-Ones Derivatives Incorporating Ultrasound and Deep Eutectic Solvent (DES) Blend of Techniques, for Some Biological Activities and Molecular Docking Studies

We have developed a new idea to synthesize a key intermediate molecule by utilizing deep eutectic solvent (DES) and ultrasound in a multistep reaction to ensure process cost-effectiveness. To confirm the stability of reagents with DES, electronic energies were calculated at the B3LYP/6-31+G(d,p) lev...

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Bibliographic Details
Main Authors: Mohd Imran, Md. Afroz Bakht, Abida Khan, Md. Tauquir Alam, El Hassane Anouar, Mohammed B. Alshammari, Noushin Ajmal, Archana Vimal, Awanish Kumar, Yassine Riadi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
thiazole-indole
des
ultrasound
anti-inflammatory
analgesic
ulcerogenic
lipid peroxidation
molecular docking
dft
Online Access:https://www.mdpi.com/1420-3049/25/5/1118

Internet

https://www.mdpi.com/1420-3049/25/5/1118

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