Age-related functional and structural retinal modifications in the Igf1−/− null mouse

Background: Mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic neurosensorial deafness. To understand the precise role of IGF-I in retinal physiology, we have studied the morphology and electrophysiology of the retina of the Igf1−/− mice in comparison with that...

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Bibliographic Details
Main Authors: L. Rodriguez-de la Rosa, L. Fernandez-Sanchez, F. Germain, S. Murillo-Cuesta, I. Varela-Nieto, P. de la Villa, N. Cuenca
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611200068X