Natural Biflavonoids Modulate Macrophage–Oxidized LDL Interaction In Vitro and Promote Atheroprotection In Vivo

Natural Biflavonoids Modulate Macrophage–Oxidized LDL Interaction In Vitro and Promote Atheroprotection In Vivo

The accumulation of oxidized ApoB-100-containing lipoproteins in the vascular intima and its subsequent recognition by macrophages results in foam cell formation and inflammation, key events during atherosclerosis development. Agents targeting this process are considered potentially atheroprotective...

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Bibliographic Details
Main Authors: Jorge H. Tabares-Guevara, Oscar J. Lara-Guzmán, Julian A. Londoño-Londoño, Jelver A. Sierra, Yudy M. León-Varela, Rafael M. Álvarez-Quintero, Edison J. Osorio, José R. Ramirez-Pineda
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
oxidized LDL
macrophage
foam cell
biflavonoid
morelloflavone
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00923/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00923/full

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