Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi

Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi

Abstract Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages. We investigated the mechanisms by which NTHi ca...

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Bibliographic Details
Main Authors: Rana M. Khalaf, Simon R. Lea, Hannah J. Metcalfe, Dave Singh
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Respiratory Research
Subjects:
Chronic Obstructive Pulmonary Disease
Glucocorticoid Receptor
Chronic Obstructive Pulmonary Disease Patient
Alveolar Macrophage
Macrophage Polarisation
Online Access:http://link.springer.com/article/10.1186/s12931-017-0539-4

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http://link.springer.com/article/10.1186/s12931-017-0539-4

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