Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.

Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.

Schistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives. Studies o...

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Bibliographic Details
Main Authors: Christin Buro, Svenja Beckmann, Katia C Oliveira, Colette Dissous, Katia Cailliau, Richard J Marhöfer, Paul M Selzer, Sergio Verjovski-Almeida, Christoph G Grevelding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4055459?pdf=render

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http://europepmc.org/articles/PMC4055459?pdf=render

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