Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics

Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics

Background: An untargeted chemical analysis of bio-fluids provides semi-quantitative data for thousands of chemicals for expanding our understanding about relationships among metabolic pathways, diseases, phenotypes and exposures. During the processing of mass spectral and chromatography data, vario...

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Bibliographic Details
Main Authors: Dinesh Kumar Barupal, Sadjad Fakouri Baygi, Robert O. Wright, Manish Arora
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Public Health
Subjects:
LC/MS
exposome
metabolomics
untargeted chemical analysis
birth weight
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2021.653599/full

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https://www.frontiersin.org/articles/10.3389/fpubh.2021.653599/full

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