Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation

Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation

Platelet/granulocyte aggregates (PGAs) increase thromboinflammation in the vasculature, and PGA formation is tightly controlled by the complement alternative pathway (AP) negative regulator, Factor H (FH). Mutations in FH are associated with the prothrombotic disease atypical hemolytic uremic syndro...

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Bibliographic Details
Main Authors: Adam Z. Blatt, Gurpanna Saggu, Claudio Cortes, Andrew P. Herbert, David Kavanagh, Daniel Ricklin, John D. Lambris, Viviana P. Ferreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
factor H
platelet
neutrophil
complement
atypical hemolytic uremic syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01586/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01586/full

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