Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer

Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer

Purpose. The biallelic inactivation of the 8-hydroxyguanine repair gene MUTYH leads to MUTYH-associated polyposis (MAP), which is characterized by colorectal multiple polyps and carcinoma(s). However, only limited information regarding MAP in the Japanese population is presently available. Since ear...

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Bibliographic Details
Main Authors: Kazuya Shinmura, Masanori Goto, Hong Tao, Hisami Kato, Rie Suzuki, Satoki Nakamura, Tomonari Matsuda, Guang Yin, Makiko Morita, Suminori Kono, Haruhiko Sugimura
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2014/617351

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http://dx.doi.org/10.1155/2014/617351

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