The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease

Folate metabolism makes a crucial contribution towards late-onset Alzheimer’s disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T polymorphism in the MTHFR gene with the susce...

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Bibliographic Details
Main Authors: Yi Jian, Xiao Lan, Zhou Sheng-Qiang, Zhang Wen-Jiang, Liu Bai-Yan
Format: Article
Language:English
Published: De Gruyter 2019-01-01
Series:Open Medicine
Subjects:
Online Access:https://doi.org/10.1515/med-2019-0006