VISPA2: a scalable pipeline for high-throughput identification and annotation of vector integration sites

VISPA2: a scalable pipeline for high-throughput identification and annotation of vector integration sites

Abstract Background Bioinformatics tools designed to identify lentiviral or retroviral vector insertion sites in the genome of host cells are used to address the safety and long-term efficacy of hematopoietic stem cell gene therapy applications and to study the clonal dynamics of hematopoietic recon...

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Bibliographic Details
Main Authors: Giulio Spinozzi, Andrea Calabria, Stefano Brasca, Stefano Beretta, Ivan Merelli, Luciano Milanesi, Eugenio Montini
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Bioinformatics
Subjects:
Open source software
Bioinformatics pipeline
Integration site analysis
Gene therapy
High-throughput sequencing
Next-generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12859-017-1937-9

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http://link.springer.com/article/10.1186/s12859-017-1937-9

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