Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

Azacitidine, an inhibitor of DNA methylation, shows therapeutic effects against several malignancies by inducing apoptosis and inhibiting tumor cell proliferation. However, the anti-tumor effects of azacitidine on urinary bladder urothelial carcinoma (UBUC), especially following intravesical instill...

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Bibliographic Details
Main Authors: Shao-Chuan Wang, Ya-Chuan Chang, Min-You Wu, Chia-Ying Yu, Sung-Lang Chen, Wen-Wei Sung
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
bladder cancer
azacitidine
intravesical instillation
TNF-R1
TRAIL-R2
Online Access:https://www.mdpi.com/2072-6694/13/16/3933

Internet

https://www.mdpi.com/2072-6694/13/16/3933

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