Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

Cellular metabolic pathways that are altered by HIV-1 infection may accelerate disease progression. Dysfunction in tryptophan (Trp) metabolism has been observed clinically in association with accelerated HIV-1 pathogenesis, but the mechanism responsible was not known. This study demonstrates that Tr...

Full description

Bibliographic Details
Main Authors: Yan-Heng Zhou, Li Sun, Jun Chen, Wei-Wei Sun, Li Ma, Yang Han, Xia Jin, Qing-Xia Zhao, Taisheng Li, Hongzhou Lu, Xiu Qiu, Jian-Hua Wang
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
hiv-1
aryl hydrocarbon receptor
tryptophan metabolite
transcription
Online Access:https://doi.org/10.1128/mBio.02591-19

Internet

https://doi.org/10.1128/mBio.02591-19

Similar Items