Mathematical simulation of tumour angiogenesis: angiopoietin balance is a key factor in vessel growth and regression

Abstract Excessive tumour growth results in a hypoxic environment around cancer cells, thus inducing tumour angiogenesis, which refers to the generation of new blood vessels from pre-existing vessels. This mechanism is biologically and physically complex, with various mathematical simulation models...

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Bibliographic Details
Main Authors: Hayato Yanagisawa, Masahiro Sugimoto, Tomoyuki Miyashita
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79824-8