Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.

Bibliographic Details
Main Authors: Sumeet Pal Singh, Sharan Janjuha, Theresa Hartmann, Özge Kayisoglu, Judith Konantz, Sarah Birke, Priyanka Murawala, Ezzaldin Ahmed Alfar, Kei Murata, Anne Eugster, Naoki Tsuji, Edward R. Morrissey, Michael Brand, Nikolay Ninov
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00461-3

Internet

https://doi.org/10.1038/s41467-017-00461-3

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