Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome

Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome

CGG expansions between 55 and 200 in the 5′-untranslated region of the fragile-X mental retardation gene (FMR1) increase the risk of developing the late-onset debilitating neuromuscular disease Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). While the science behind this mutation, as a paradigm...

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Bibliographic Details
Main Authors: Eleonora Napoli, Amanda Flores, Yasmeen Mansuri, Randi J. Hagerman, Cecilia Giulivi
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Triplet nucleotide repeat diseases
Bioenergetics
Fibroblasts
Brain
Antioxidants
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001765

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http://www.sciencedirect.com/science/article/pii/S0969996121001765

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