PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes

PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes

Abstract Background Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit formation of breast-cancer-derived experimental lung metastasis. Further, high expression of PLCγ1 and its constitutively...

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Bibliographic Details
Main Authors: Rossano Lattanzio, Manuela Iezzi, Gianluca Sala, Nicola Tinari, Marco Falasca, Saverio Alberti, Simonetta Buglioni, Marcella Mottolese, Letizia Perracchio, Pier Giorgio Natali, Mauro Piantelli
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Breast cancer
Phospholipase Cγ1
Prognosis
Luminal subtypes
Menopausal status
Online Access:http://link.springer.com/article/10.1186/s12885-019-5949-x

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http://link.springer.com/article/10.1186/s12885-019-5949-x

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