IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the i...

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Bibliographic Details
Main Authors: Alyssa Batista, Jeffrey J Rodvold, Su Xian, Stephen C Searles, Alyssa Lew, Takao Iwawaki, Gonzalo Almanza, T Cameron Waller, Jonathan Lin, Kristen Jepsen, Hannah Carter, Maurizio Zanetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000687

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https://doi.org/10.1371/journal.pbio.3000687

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