Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy

Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy

Abstract Background Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to respond to standard vasodilator therapy targeting the major vasoactive pathways, causing a high morbidity and mort...

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Bibliographic Details
Main Authors: Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Robbert J. Rottier
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Respiratory Research
Subjects:
Nitric oxide
Endothelin
Prostacyclin
Development
Lung
Vasculature
Online Access:http://link.springer.com/article/10.1186/s12931-017-0670-2

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http://link.springer.com/article/10.1186/s12931-017-0670-2

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