Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on t...

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Bibliographic Details
Main Authors: Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, Ketan Patel
Format: Article
Language:English
Published: PAGEPress Publications 2020-01-01
Series:European Journal of Translational Myology
Subjects:
Muscle hypertrophy
Testis
Activin
Myostatin
Online Access:https://pagepressjournals.org/index.php/bam/article/view/8737

Internet

https://pagepressjournals.org/index.php/bam/article/view/8737

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