AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.

AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.

A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and integrate G-protein signaling events to regulate development, physiology, and disease. One family member, AKAP13, encodes for multiple protein isoforms that contain binding sites for protein kinase A (PKA) and D (PKD)...

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Bibliographic Details
Main Authors: Matthew J Spindler, Brian T Burmeister, Yu Huang, Edward C Hsiao, Nathan Salomonis, Mark J Scott, Deepak Srivastava, Graeme K Carnegie, Bruce R Conklin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3637253?pdf=render

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http://europepmc.org/articles/PMC3637253?pdf=render

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