Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1

Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1

Abstract Background Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist. Our aim was evaluation of PD-L1-expressing monocytic myeloid-derived suppressor cells (M-MDSCs), monocytes/...

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Bibliographic Details
Main Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło, Jan Kotarski
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
M-MDSC
Monocytes/macrophages
PD-L1
sPD-L1
TMEs
Online Access:http://link.springer.com/article/10.1186/s12967-020-02389-7

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http://link.springer.com/article/10.1186/s12967-020-02389-7

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