Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases. Optic Atrophy Type 1 (OPA1), a mitochondrial fusion protein, has recently been...

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Bibliographic Details
Main Authors: Xinxin Hu, Yi Dai, Rong Zhang, Kunte Shang, Xinghuai Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
OPA1
parkin
retinal ganglion cells
mitochondria
glaucoma
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00350/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00350/full

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