Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs

Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs

Potassium channels are important regulators of cellular homeostasis and targeting these proteins pharmacologically is unveiling important mechanisms in cancer cell biology. Here we demonstrate that pharmacological stimulation of the Kv11.1 potassium channel activity results in mitochondrial reactive...

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Bibliographic Details
Main Authors: Vitalyi Senyuk, Najmeh Eskandari, Ying Jiang, Rebeca Garcia-Varela, Rachel Sundstrom, Luigi Leanza, Roberta Peruzzo, Mark Burkard, Richard D. Minshall, Saverio Gentile
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Redox Biology
Subjects:
NRF2
Potassium channels
Mitochondria
Cancer cell survival
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001889

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http://www.sciencedirect.com/science/article/pii/S2213231721001889

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