AOA-2 Derivatives as Outer Membrane Protein A Inhibitors for Treatment of Gram-Negative Bacilli Infections

AOA-2 Derivatives as Outer Membrane Protein A Inhibitors for Treatment of Gram-Negative Bacilli Infections

Previously, we identified that a cyclic hexapeptide AOA-2 inhibited the interaction of Gram-negative bacilli (GNB) like Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli to host cells thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model...

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Bibliographic Details
Main Authors: Rafael Ayerbe-Algaba, Nuria Bayó, Ester Verdú, Raquel Parra-Millán, Jesús Seco, Meritxell Teixidó, Jerónimo Pachón, Ernest Giralt, Younes Smani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
AOA-2 derivatives
outer membrane protein A
inhibitor
Gram-negative bacilli
peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.634323/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.634323/full

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